Cubs Face Rays in Interleague MLB Matchup: Preview and Odds

The Chicago Cubs are set to play the Tampa Bay Rays in an interleague game. The match is scheduled for Monday afternoon at Tropicana Field in St. Petersburg, Fla.

The Cubs are coming off a doubleheader split with the Cleveland Guardians. They won the first game 1-0, but lost the second 6-5. The Rays defeated Minnesota 4-1 on Sunday.

Latest Odds and Predictions

Tampa Bay is a -124 favourite on the money line. The over/under is set at 8.

A SportsLine Projection Model has simulated the game 10,000 times. The model was profitable on top-rated MLB money-line picks last season, going 35-29. It also excelled at making home run prop picks in 2025, returning nearly 30 units of profit.

The model has locked in its picks and MLB predictions for Cubs vs. Rays. You can find these at SportsLine.

Projected Player Performances

The SportsLine model projects more than 1.48 total bases for several players. These include Michael Busch, Alex Bregman, Ian Happ, Pete Crow-Armstrong, Nico Hoerner and Carson Kelly. The Rays are projected to get over 1.5 total bases from Yandy Diaz, Jonathan Aranda, Junior Caminero and Nick Fortes.

The model projects 9.4 combined runs. The Over hits in 66% of simulations.

Team Statistics and Offence

Tampa Bay enters the game with MLB’s sixth-best offence, hitting .265 on the season. The Rays also have the ninth-best slugging percentage at .391.

  • Last season, Tampa Bay hit .251 as a team.
  • Chicago was 13th at .249.

Looking Ahead

The Cubs finished second in the National League Central at 92-70 a year ago. They were 42-39 on the road. The Rays finished fourth in the American League East in 2025, with a 41-40 record on their home field.

The SportsLine model also indicates that one side of the money line holds significant value after simulating every pitch 10,000 times.

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